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Cd83tm1Tft
Targeted Allele Detail
Nomenclature
Symbol: Cd83tm1Tft
Name: CD83 antigen; targeted mutation 1, Thomas F Tedder
MGI ID: MGI:2676282
Synonyms: CD83-
Gene: Cd83  Location: Chr13:43785112-43803133 bp, + strand  Genetic Position: Chr13, 21.6 cM, cytoband A4-5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75700
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA sequence fragment extending from within exon 3 through the coding region of exon 5 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 25 residues of the immunoglobulin-like domain and the transmembrane and cytoplasmic domains. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of LPS-stimulated bone marrow-derived dendritic cells. (J:75700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd83 Mutation:  10 strains or lines available
References
Original:  J:75700 Fujimoto Y, et al., CD83 Expression Influences CD4(+) T Cell Development in the Thymus. Cell. 2002 Mar 22;108(6):755-67
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory