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Esr2tm1Psh
Targeted Allele Detail
Nomenclature
Symbol: Esr2tm1Psh
Name: estrogen receptor 2 (beta); targeted mutation 1, Paul J Shughrue
MGI ID: MGI:2676193
Synonyms: ERBeta(-), ERBetaKO
Gene: Esr2  Location: Chr12:76120419-76177259 bp, - strand  Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76322
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details2 kb of genomic sequence encompassing portions of exons 1 and 2 as well as the intervening intron were replaced with a cassette containing translational stop codons in all three reading frames, followed by a floxed neomycin resistance gene. The absence of protein was confirmed by Western blot analysis and by immunocytochemistry. (J:76322)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr2 Mutation:  9 strains or lines available
References
Original:  J:76322 Shughrue PJ, et al., Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain. Endocrinology. 2002 May;143(5):1643-50
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory