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Ctf1tm1Msd
Targeted Allele Detail
Nomenclature
Symbol: Ctf1tm1Msd
Name: cardiotrophin 1; targeted mutation 1, Michael Sendtner
MGI ID: MGI:2675769
Synonyms: ct-1 -
Gene: Ctf1  Location: Chr7:127712736-127718192 bp, + strand  Genetic Position: Chr7, 69.69 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77294
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment spanning exon 2 and the complete coding region of exon 3. In situ hybridization studies on homozygous embryos demonstrated that no detectable transcript is expressed from this allele. (J:77294)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctf1 Mutation:  10 strains or lines available
References
Original:  J:77294 Oppenheim RW, et al., Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons. J Neurosci. 2001 Feb 15;21(4):1283-91
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory