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Targeted Allele Detail
Symbol: Hoxc8tm1.1Rud
Name: homeobox C8; targeted mutation 1.1, Frank H Ruddle
MGI ID: MGI:2675412
Synonyms: EElox
Gene: Hoxc8  Location: Chr15:102990607-102994111 bp, + strand  Genetic Position: Chr15, 58.05 cM
Germline Transmission:  Earliest citation of germline transmission: J:85471
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Hypomorph)
Mutation:    Other
Mutation detailsA hypomorphic allele was generated by deleting the early enhancer (EE) via homologous and cre-mediated recombination. The EE is a 200 bp region approximately 3 kb upstream of the coding region containing several putative transcription factor binding sites. This allele differs from Hoxc8tm1Rud in that the floxed neo cassette was excised prior to germline transmission, leaving a single loxP site in place of the deleted region. (J:85471)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 23 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxc8 Mutation:  1 strain or line available
Original:  J:85471 Juan AH, et al., Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer. Development. 2003 Oct;130(20):4823-34
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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