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QTL Variant Detail
QTL variant: Pgia27BALB/cCrl
Name: proteoglycan induced arthritis 27; BALB/cCrl
MGI ID: MGI:2675323
QTL: Pgia27  Location: Chr4:87067227-87067464 bp  Genetic Position: Chr4, cM position of peak correlated region/allele: 40.86 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  BALB/cCrl
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.

Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9, Pgia12.

The authors cite the following marker as having been previously mapped; however, differing parental strains were used in the previous map studies. We have renamed the QTL as follows:

The authors refer to Pgia13 on mouse chromosome 4. This QTL was originally mapped using an

(C57BL/6x C3H/HeJCr)F2 intercross. We have renamed the QTL Pgia35, mapped here using (BALB/cCrl x DBA/2Crl)F2 mice. This QTL maps to mouse chromosome 4 at D4Mit97 with LOD=3.1 for arthritis severity in male mice. The Pgia35 interval spanned 0-20cM on mouse chr 4.

Authors identify novel PGIA loci:

Pgia26 mapped to 52.5 cM on mouse Chromosome 3 with LOD=4.9 at D3Mit158 for arthritis onset in female animals. The Pgia26 QTL interval spans 34 cM - 80 cM on chromosome 3. BALB/cCrl-derived alleles confer high arthritis onset with codominant inheritance at Pgia26.

Pgia27 mapped to 42.5 cM on mouse Chromosome 4 with LOD=3.1 at D4Mit45 for arthritis severity in male animals. The Pgia27 QTL interval spans 35 - 45 cM on chromosome 4.

Pgia28 mapped to 14 cM on mouse Chromosome 11 with LOD=2.8atD11Mit229 for hetero antibody production in male animals. The Pgia28 QTL range spans 0 cM - 28 cM on chromosome 11.

Pgia29 mapped to 45 cM on mouse Chromosome 14 with LOD=2.8 forarthritis severity in male animals andLOD=3.5 forT cell proliferationinfemale animals at D14Mit92. The Pgia29 QTL range spans 40 cM - 54 cM on chromosome 14.

Original:  J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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