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Men1tm1.2Zqw
Targeted Allele Detail
Nomenclature
Symbol: Men1tm1.2Zqw
Name: multiple endocrine neoplasia 1; targeted mutation 1, Zhao-Qi Wang
MGI ID: MGI:2675250
Synonyms: Men1F
Gene: Men1  Location: Chr19:6334979-6340891 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85133
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsSingle loxP sites were left flanking exon 3 after floxed sequence encompassing the neomycin resistance gene and the thymidine kinase gene was removed from Men1tm1Zqw via expression of cre recombinase in the germline. (J:85133)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  17 strains or lines available
References
Original:  J:85133 Bertolino P, et al., Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res. 2003 Aug 15;63(16):4836-41
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory