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Rasgrp1lag
Spontaneous Allele Detail
Nomenclature
Symbol: Rasgrp1lag
Name: RAS guanyl releasing protein 1; lymphoproliferation autoimmunity glomerulonephritis
MGI ID: MGI:2675033
Gene: Rasgrp1  Location: Chr2:117279983-117342877 bp, - strand  Genetic Position: Chr2, 59.19 cM
Mutation
origin
Strain of Origin:  129
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation detailsThe spontaneous mutation that arose on a 129 background results in the generation of 2 aberrantly spliced transcripts that lack exon 4 and are putatively translated into nonfunctional polypeptides. The mutation suppresses the use of the splice donor site located at the beginning of intron 3 and enables the utilization of cryptic splice sites located in intron 3 resulting in the splicing of intron 3 to exon 5. (J:85189)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rasgrp1 Mutation:  28 strains or lines available
References
Original:  J:85189 Layer K, et al., Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity. 2003 Aug;19(2):243-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory