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EdnrbWS4
Spontaneous Allele Detail
Summary
Symbol: EdnrbWS4
Name: endothelin receptor type B; Waardenburg syndrome 4
MGI ID: MGI:2674291
Synonyms: WS4
Gene: Ednrb  Location: Chr14:104052061-104081838 bp, - strand  Genetic Position: Chr14, 53.05 cM
Alliance: EdnrbWS4 page
Cochlea comparison of wild type and EdnrbWS4/EdnrbWS4 mice at 6 weeks of age

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  (BALB/c x MSM)F1
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThe WS4 mouse arose spontaneously at the Saitama Research Center, Saitama, Japan. The mutation was shown to be allelic to Ednrbs-l by a non-complementation test. Analysis of a cDNA derived from mutant mice revealed that a deletion of nucleotides encoding 106 amino acids corresponding to exons 2 and 3 had occurred. (J:76584, J:115266)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:  90 strains or lines available
References
Original:  J:76584 Matsushima Y, et al., A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene. Mamm Genome. 2002 Jan;13(1):30-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory