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Targeted Allele Detail
Symbol: Cldn14tm1Tbf
Name: claudin 14; targeted mutation 1, Thomas B Friedman
MGI ID: MGI:2674077
Synonyms: Cldn14-
Gene: Cldn14  Location: Chr16:93919032-94008837 bp, - strand  Genetic Position: Chr16, 54.99 cM, cytoband C3-4
Germline Transmission:  Earliest citation of germline transmission: J:85071
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3' portion of exon 3 was replaced with lacZ and neo, both simaltaneously inserted via homologous recombination of a targeting vector. The expression pattern of lacZ recapitulated that of the endogenous gene. Transcript was undetected by RT-PCR analysis of mRNA obtained from homozygous mutant kidneys. Immunostaining showed an absence of protein in sensory hair cells of homozygous mutant mice. (J:85071)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cldn14 Mutation:  64 strains or lines available
Original:  J:85071 Ben-Yosef T, et al., Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet. 2003 Aug 15;12(16):2049-61
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory