Serpinb6atm1Pib
Targeted Allele Detail
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Symbol: |
Serpinb6atm1Pib |
Name: |
serine (or cysteine) peptidase inhibitor, clade B, member 6a; targeted mutation 1, Phillip I Bird |
MGI ID: |
MGI:2673996 |
Gene: |
Serpinb6a Location: Chr13:34101901-34186777 bp, - strand Genetic Position: Chr13, 14.0 cM
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Alliance: |
Serpinb6atm1Pib page
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Germline Transmission: |
Earliest citation of germline transmission:
J:85039
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was replaced with a cassette containing EGFP followed by floxed neo. GFP was expressed by the endogenous promoter and regulatory elements, however, comparison with endogenous expression and with Serpinb6atm1.1Pib GFP expression indicated that retention of the neo cassette increased expression levels. Western blot analysis indicated an absence of normal protein in homozygous mutant spleen and thymus tissue.
(J:85039)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Serpinb6a Mutation: |
26 strains or lines available
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Original: |
J:85039 Scarff KL, et al., A retained selection cassette increases reporter gene expression without affecting tissue distribution in SPI3 knockout/GFP knock-in mice. Genesis. 2003 Jul;36(3):149-57 |
All: |
1 reference(s) |
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