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Targeted Allele Detail
Symbol: Serpinb6atm1Pib
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6a; targeted mutation 1, Phillip I Bird
MGI ID: MGI:2673996
Gene: Serpinb6a  Location: Chr13:33917918-34002794 bp, - strand  Genetic Position: Chr13, 14.0 cM
Germline Transmission:  Earliest citation of germline transmission: J:85039
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a cassette containing EGFP followed by floxed neo. GFP was expressed by the endogenous promoter and regulatory elements, however, comparison with endogenous expression and with Serpinb6atm1.1Pib GFP expression indicated that retention of the neo cassette increased expression levels. Western blot analysis indicated an absence of normal protein in homozygous mutant spleen and thymus tissue. (J:85039)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpinb6a Mutation:  4 strains or lines available
Original:  J:85039 Scarff KL, et al., A retained selection cassette increases reporter gene expression without affecting tissue distribution in SPI3 knockout/GFP knock-in mice. Genesis. 2003 Jul;36(3):149-57
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory