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Icosltm1Kplm
Targeted Allele Detail
Nomenclature
Symbol: Icosltm1Kplm
Name: icos ligand; targeted mutation 1, Kong-Peng Lam
MGI ID: MGI:2673557
Synonyms: B7-H2-, B7RP-1
Gene: Icosl  Location: Chr10:78069368-78079525 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84893
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing a portion of the promoter and exons encoding the initiator methionine, signal peptide, and IgV-like domain were replaced with a neomycin resistance gene inserted by homologous recombination. Neither full length nor truncated transcript was detected by Northern blot or RT-PCR analyses of message isolated from homozygous mutant spleen tissue. (J:84893)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Icosl Mutation:  6 strains or lines available
References
Original:  J:84893 Wong SC, et al., Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2. Blood. 2003 Aug 15;102(4):1381-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory