Icosl^tm1Kplm
Targeted Allele Detail

Summary

• Symbol: Icosl^tm1Kplm
• Name: icos ligand; targeted mutation 1, Kong-Peng Lam
• MGI ID: MGI:2673557
• Synonyms: B7-H2^-, B7RP-1
• Gene: Icosl Location: Chr10:77904921-77915359 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Icosl^tm1Kplm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84893
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing a portion of the promoter and exons encoding the initiator methionine, signal peptide, and IgV-like domain were replaced with a neomycin resistance gene inserted by homologous recombination. Neither full length nor truncated transcript was detected by Northern blot or RT-PCR analyses of message isolated from homozygous mutant spleen tissue. (J:84893)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Icosl Mutation: 27 strains or lines available

References

• Original: J:84893 Wong SC, et al., Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2. Blood. 2003 Aug 15;102(4):1381-8
• All: 8 reference(s)