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Targeted Allele Detail
Symbol: Stat3tm1Desi
Name: signal transducer and activator of transcription 3; targeted mutation 1, Stephen Desiderio
MGI ID: MGI:2673309
Synonyms: Stat3Beta-
Gene: Stat3  Location: Chr11:100885098-100939540 bp, - strand  Genetic Position: Chr11, 63.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:77307
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Nucleotide substitutions
Mutation detailsExon 23 was replaced with modified sequence in which nucleotide susbtitutions within 3 polypyrimidine tracts and an AG dinucleotide were made in order to disrupt an internal splice acceptor site specific to the beta isoform. Transcript encoding the beta isoform was undetected by RT-PCR analysis of homozygous mutant hepatic mRNA, while wild-type levels of transcript encoding the alpha isoform were observed. Analysis of MEFs reiterated these findings at the protein level. (J:77307)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:  30 strains or lines available
Original:  J:77307 Yoo JY, et al., Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell. 2002 Feb 8;108(3):331-44
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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