Cd3g^tm2Amk
Targeted Allele Detail

Summary

• Symbol: Cd3g^tm2Amk
• Name: CD3 antigen, gamma polypeptide; targeted mutation 2, Ada M Kruisbeek
• MGI ID: MGI:2673301
• Synonyms: CD3gamma^deltaI, CD3gamma-deltaITAM
• Gene: Cd3g Location: Chr9:44880870-44891729 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cd3g^tm2Amk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77504
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 5 and all of exon 6 were deleted by the incorporation of a targeting vector. The deleted region included sequence encoding the ITAM domain. While protein was undetected by immunoprecipitation, it was detected in homozygous mutant mice by SDS-PAGE, putatively because the anti-Cd3g serum recognizes epitopes present in the deleted region. (J:77504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd3g Mutation: 24 strains or lines available

References

• Original: J:77504 Haks MC, et al., A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activation motif in mature T cell function. J Immunol. 2001 Feb 15;166(4):2576-88
• All: 1 reference(s)