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Miftm1Gfr
Targeted Allele Detail
Nomenclature
Symbol: Miftm1Gfr
Name: macrophage migration inhibitory factor; targeted mutation 1, G Fingerle-Rowson
MGI ID: MGI:2673280
Synonyms: MIF-
Gene: Mif  Location: Chr10:75859353-75860250 bp, - strand  Genetic Position: Chr10, 38.59 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84791
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe endogenous locus was replaced with a single loxP site after the transient expression of cre recombinase in ES cells deleted sequence encompassing (from 5' to 3') the 3' end of a nonfunctional retrotransposon of the intracisternalA particle (IAP), the promoter, and exons 1 through 3. Neither transcript nor protein was detected in homozygous mutant mice by Northern and Western blot analyses. (J:84791)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mif Mutation:  5 strains or lines available
References
Original:  J:84791 Fingerle-Rowson G, et al., The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9354-9
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory