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Gata2tm1Mym
Targeted Allele Detail
Nomenclature
Symbol: Gata2tm1Mym
Name: GATA binding protein 2; targeted mutation 1, Masayuki Yamamoto
MGI ID: MGI:2673268
Synonyms: EII-KI, Gata2gfp
Gene: Gata2  Location: Chr6:88193891-88207032 bp, + strand  Genetic Position: Chr6, 39.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84836
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encoding green fluorescent protein (GFP) was inserted in exon II, replacing the first coding exon. A floxed neo cassette that was included in the initial targeting vector was removed via cre mediated recombination. The profile of GFP expression was consistent with that of the endogenous expression. (J:84836, J:106045)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 17 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata2 Mutation:  17 strains or lines available
References
Original:  J:84836 Minegishi N, et al., Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. Blood. 2003 Aug 1;102(3):896-905
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory