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Tg(Thy1-MAPT)183Gotz
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-MAPT)183Gotz
Name: transgene insertion 183, Jurgen Gotz
MGI ID: MGI:2672839
Synonyms: P301L tau, pR5
Transgene: Tg(Thy1-MAPT)183Gotz  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT)183Gotz expresses 1 gene
 
Mutation detailsSequence encoding the longest human MAPT brain isoform (tau40), consisting of exons 2 and 3 as well as four microtubule-binding repeats, was adjoined to the murine Thy1 promoter. The human MAPT sequence included the P301L point mutation, which is linked to human frontotemporal dementia with parkinsonism. Soluble levels of transgenic protein in the brain were approximately 70% of the endogenous level. Expression levels of transgenic protein were high in the hippocampus, fornix fimbriae, amygdala, spinal cord, and cortex, weaker in brain stem and striatum, and not detectable in the olfactory bulb and cerebellum. (J:66831)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:66831 Gotz J, et al., Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem. 2001 Jan 5;276(1):529-34
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory