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Mc4rGlu3
Chemically induced Allele Detail
Nomenclature
Symbol: Mc4rGlu3
Name: melanocortin 4 receptor; glucose3
MGI ID: MGI:2671841
Synonyms: Fatboy, FB, Glum03Jus
Gene: Mc4r  Location: Chr18:66857715-66860472 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Obesity is observed in Mc4rGlu3/Mc4rGlu3 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Mutagenesis for Dev. Defects
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. The molecular lesion was identified as a T-to-C transition mutation in codon 194, which results in a isoleucine to threonine change in the encoded protein. (J:116205)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:  13 strains or lines available
References
Original:  J:85113 Kile BT, et al., Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory