Kmt2a^{T(4Mllt3;9Mll)1Thr}
Targeted Allele Detail

Summary

• Symbol: Kmt2a^{T(4Mllt3;9Mll)1Thr}
• Name: lysine (K)-specific methyltransferase 2A; reciprocal translocation 1, Ch 4 and Ch 9, Terrence H Rabbitts
• MGI ID: MGI:2671705
• Synonyms: t(4;9) Mll-AF9 fusion
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^{T(4Mllt3;9Mll)1Thr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68500
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted
• Mutation: Translocation
• Mutation details: The T(4Mllt3;9Mll)1Thr translocation was engineered to recapitulate the leukemia-associated human T(9;11)(p22;q23) translocation. The translocation was generated by interchromosomal cre mediated recombination of single loxP sites within Mll^tm1Thr and Mllt3^tm2Thr. Fusion transcript containing exon 8 of Mll and exon b of Mllt3 was identified in various tissues of mutant mice by RT-PCR analysis. (J:68500)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 137 strains or lines available

References

• Original: J:68500 Collins EC, et al., Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep. 2000 Aug;1(2):127-32
• All: 2 reference(s)