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Targeted Allele Detail
Symbol: Runx1tm1Buch
Name: runt related transcription factor 1; targeted mutation 1, Frank Buchholz
MGI ID: MGI:2671464
Synonyms: AMLX
Gene: Runx1  Location: Chr16:92601466-92826149 bp, - strand  Genetic Position: Chr16, 53.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:68499
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Humanized sequence)
Mutation:    Other
Mutation detailsA floxed neo cassette was inserted into intron 5, 1496 bp downstream of exon 5. This allele, in combination with allele Runx1t1tm1Buch in the same cells was used for the engineering of T(4;16), a reciporical translocation that replicates the human acute myeloid leukemia (AML) associated translocation, T(8;21). (J:68499)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  18 strains or lines available
Original:  J:68499 Buchholz F, et al., Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug;1(2):133-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory