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Runx1tm1Buch
Targeted Allele Detail
Nomenclature
Symbol: Runx1tm1Buch
Name: runt related transcription factor 1; targeted mutation 1, Frank Buchholz
MGI ID: MGI:2671464
Synonyms: AMLX
Gene: Runx1  Location: Chr16:92601466-92826149 bp, - strand  Genetic Position: Chr16, 53.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68499
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Other
 
Mutation detailsA floxed neo cassette was inserted into intron 5, 1496 bp downstream of exon 5. This allele was initially generated for use in the engineering of T(4;16), a reciporical translocation that replicates the human acute myeloid leukemia (AML) associated translocation, T(8;21). (J:68499)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  13 strains or lines available
References
Original:  J:68499 Buchholz F, et al., Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug;1(2):133-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory