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Targeted Allele Detail
Symbol: Rdxtm1Sts
Name: radixin; targeted mutation 1, Shoichiro Tsukita
MGI ID: MGI:2671151
Synonyms: Rdx-
Gene: Rdx  Location: Chr9:52047150-52088737 bp, + strand  Genetic Position: Chr9, 28.62 cM
Stereocilia abnormalities on Rdxtm1Sts/Rdxtm1Sts cochlear hair cells of adult and newborn mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77485
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment including exon 3 was replaced with a cassette containing a spice acceptor sie, an internal ribosomal entry site followed by a lacZ gene, and a neomycin selection gene. Western blot analysis of kidney and liver proteins derived from homozygous mice demonstrated that no detectable protein was made from this allele. (J:77485)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdx Mutation:  14 strains or lines available
Original:  J:77485 Kikuchi S, et al., Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002 Jul;31(3):320-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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