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Tg(SOD1*G93A)dl1Gur
Transgene Detail
Nomenclature
Symbol: Tg(SOD1*G93A)dl1Gur
Name: transgene insertion dl 1, Mark E Gurney
MGI ID: MGI:2671112
Synonyms: G1L, G93A SOD1, mSOD1-Tg, TgNSOD1-G93A, TgN(SOD1-G93A)1Gurdl, TgN(SOD1-G93A)1Gurdl, TgN[SOD1-G93A]dl1Gur, Tg(SOD1-G93A)dl1Gur
Transgene: Tg(SOD1*G93A)dl1Gur  Location: unknown  Genetic Position: Chr12, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Transgenic mice on a C57BL/6 congenic background exhibit paralysis resulting in a reduced life expectancy, and may serve as a model for human amyotrophic lateral sclerosis (ALS). Paralysis in these mice is due to loss of motor neurons from the spinal cord. The onset of the ALS phenotype in these mice is delayed compared to mice carrying the original high copy number transgene Tg(SOD1*G93A)1Gur.

Transgenic mice on a genetic background involving C57BL/6 and SJL become paralyzed in one or more limbs beginning around six to seven months of age. Life expectancy for these mice is normally four to six weeks beyond onset of symptoms.

References
Original:  J:106420 Zhang B, et al., Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J Cell Biol. 1997 Dec 1;139(5):1307-15
All:  53 reference(s)

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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory