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Mapttm1(EGFP)Klt
Targeted Allele Detail
Nomenclature
Symbol: Mapttm1(EGFP)Klt
Name: microtubule-associated protein tau; targeted mutation 1, Kerry Lee Tucker
MGI ID: MGI:2670768
Synonyms: Mapttm1(GFP)Klt, tauGFP, tau ko
Gene: Mapt  Location: Chr11:104231390-104332090 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66561
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 1 was disrupted by the insertion of a cassette encoding EGFP and neo. Fusion protein including GFP was detected by Western blot analysis of homozygous mutant brain lysates. Fluorescent illumination indicated that expression of the reporter gene was similar to that of the endogenous gene. (J:66561)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 1 line available
Carrying any Mapt Mutation:  396 strains or lines available
References
Original:  J:66561 Tucker KL, et al., Neurotrophins are required for nerve growth during development. Nat Neurosci. 2001 Jan;4(1):29-37
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory