About   Help   FAQ
H2afxtm1Fwa
Targeted Allele Detail
Nomenclature
Symbol: H2afxtm1Fwa
Name: H2A histone family, member X; targeted mutation 1, Frederick W Alt
MGI ID: MGI:2670743
Synonyms: H2AXdelta
Gene: H2afx  Location: Chr9:44334694-44336077 bp, + strand  Genetic Position: Chr9, 24.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84879
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsEndogenous sequence encompassing the promoter, single exon, and poly A site was floxed and subsequently excised via cre-mediated recombination in ES cells, leaving a single loxP site in place of the endogenous gene. (J:84909)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H2afx Mutation:  2 strains or lines available
References
Original:  J:84879 Bassing CH, et al., Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell. 2003 Aug 8;114(3):359-70
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/25/2015
MGI 5.21
The Jackson Laboratory