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Targeted Allele Detail
Symbol: Ksr1tm1Kole
Name: kinase suppressor of ras 1; targeted mutation 1, Richard Kolenick
MGI ID: MGI:2670726
Synonyms: ksr1-
Gene: Ksr1  Location: Chr11:79013440-79146407 bp, - strand  Genetic Position: Chr11, 46.74 cM, cytoband B5
Germline Transmission:  Earliest citation of germline transmission: J:84644
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encoding the initiator methionine and 74 downstream amino acids encompassing 85% of the unique CA1 domain was replaced with a neomycin selection cassette. Transcript was undetected by Northern blot analysis of homozygous mutant mice. Similarly, no protein was detected in homozygotes by Western blot analysis. (J:84644)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ksr1 Mutation:  13 strains or lines available
Original:  J:84644 Lozano J, et al., Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res. 2003 Jul 15;63(14):4232-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory