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Targeted Allele Detail
Symbol: Pdgfbtm3Cbet
Name: platelet derived growth factor, B polypeptide; targeted mutation 3, Christer Betsholtz
MGI ID: MGI:2670572
Gene: Pdgfb  Location: Chr15:79995900-80014808 bp, - strand  Genetic Position: Chr15, 37.85 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:84701
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA stop codon was inserted into exon 6 via homologous recombination of a targeting vector which also included a loxP flanked neo cassette in intron 5. The insertion of the stop codon precludes the translation of the retention moftif. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Pdgfbtm3.1Cbet. (J:84701)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfb Mutation:  6 strains or lines available
Original:  J:84701 Lindblom P, et al., Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev. 2003 Aug 1;17(15):1835-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory