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Rgntm1Aish
Targeted Allele Detail
Nomenclature
Symbol: Rgntm1Aish
Name: regucalcin; targeted mutation 1, Akihito Ishigami
MGI ID: MGI:2670511
Synonyms: SMP30 -, SMP30/GNL knockout
Gene: Rgn  Location: ChrX:20549787-20562089 bp, + strand  Genetic Position: ChrX, 16.04 cM
Osteogenic disorder in vitamin C-deficient Rgntm1Aish/Y mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79342
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon III was disrupted by the insertion of a neomycin gene. The absence of gene product was proven by Western blot analysis of liver extracts from hemizygous males and homozygous females. (J:79342)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgn Mutation:  2 strains or lines available
References
Original:  J:79342 Ishigami A, et al., Senescence Marker Protein-30 Knockout Mouse Liver Is Highly Susceptible to Tumor Necrosis Factor-alpha- and Fas-Mediated Apoptosis. Am J Pathol. 2002 Oct;161(4):1273-81
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory