Rgn^tm1Aish
Targeted Allele Detail

Summary

• Symbol: Rgn^tm1Aish
• Name: regucalcin; targeted mutation 1, Akihito Ishigami
• MGI ID: MGI:2670511
• Synonyms: SMP30 -, SMP30/GNL knockout
• Gene: Rgn Location: ChrX:20416026-20428328 bp, + strand Genetic Position: ChrX, 16.04 cM
• Alliance: Rgn^tm1Aish page

Osteogenic disorder in vitamin C-deficient Rgn^tm1Aish/Y mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79342
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon III was disrupted by the insertion of a neomycin gene. The absence of gene product was proven by Western blot analysis of liver extracts from hemizygous males and homozygous females. (J:79342)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgn Mutation: 5 strains or lines available

References

• Original: J:79342 Ishigami A, et al., Senescence Marker Protein-30 Knockout Mouse Liver Is Highly Susceptible to Tumor Necrosis Factor-alpha- and Fas-Mediated Apoptosis. Am J Pathol. 2002 Oct;161(4):1273-81
• All: 32 reference(s)