Fen1^tm1Klng
Targeted Allele Detail

Summary

• Symbol: Fen1^tm1Klng
• Name: flap structure specific endonuclease 1; targeted mutation 1, Arne Klungland
• MGI ID: MGI:2670036
• Synonyms: Fen1^-
• Gene: Fen1 Location: Chr19:10176496-10181533 bp, - strand Genetic Position: Chr19, 6.54 cM
• Alliance: Fen1^tm1Klng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84556
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, containing the entire open reading frame, was replaced with a neomycin selection cassette inserted by homologous recombination. (J:84556)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fen1 Mutation: 30 strains or lines available

References

• Original: J:84556 Larsen E, et al., Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage. Mol Cell Biol. 2003 Aug;23(15):5346-53
• All: 2 reference(s)