About   Help   FAQ
Targeted Allele Detail
Symbol: Skiltm1Spw
Name: SKI-like; targeted mutation 1, Sonia Pearson-White
MGI ID: MGI:2670010
Synonyms: Sno5delta
Gene: Skil  Location: Chr3:31095058-31122577 bp, + strand  Genetic Position: Chr3, 15.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:84554
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin gene replaced 1.7kb of the promotor region immediately upstream of the ATG initiation codon. Both the mRNA transcription product and the resulting protein were produced at reduced levels in the resulting mice. (J:84554)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Skil Mutation:  18 strains or lines available
Original:  J:84554 Pearson-White S, et al., Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene. Mol Cell Biol. 2003 Aug;23(15):5446-59
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory