Tep1^tm1Leah
Targeted Allele Detail

Summary

• Symbol: Tep1^tm1Leah
• Name: telomerase associated protein 1; targeted mutation 1, Lea Harrington
• MGI ID: MGI:2669947
• Synonyms: mTep1^-, Tep1^-
• Gene: Tep1 Location: Chr14:51061516-51108017 bp, - strand Genetic Position: Chr14, 26.26 cM, cytoband C2-D1
• Alliance: Tep1^tm1Leah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84545
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Four exons were replaced with a neomycin resistance gene. No detectable gene transcripts were found by Northern blot analysis. Further, no protein product could be identified in mouse embryo fibroblast extracts by immunoblot analysis. (J:84545)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tep1 Mutation: 117 strains or lines available

References

• Original: J:84545 Liu Y, et al., Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Mol Cell Biol. 2000 Nov;20(21):8178-84
• All: 4 reference(s)