About   Help   FAQ
Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(cre/ERT)Nat
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans
MGI ID: MGI:2669525
Synonyms: CreERT1, Gt(ROSA)26Sortm1(cre/Esr1)Nat, R26CreER, R26ERCre, R26RNatCre
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Endothelial Alk1 deletion from the Acvrl1tm2.1Spo allele resulted in postnatal lethality by P5, with areteriovenous malformations in the brain, lung, and GI tract

Show the 10 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:84747
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Mutation detailsA cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen. (J:84747)
Inheritance:    Dominant
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor     Summary of all recombinase alleles driven by Gt(ROSA)26Sor.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  364 strains or lines available
Original:  J:84747 Badea TC, et al., A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci. 2003 Mar 15;23(6):2314-22
All:  100 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.08
The Jackson Laboratory