About   Help   FAQ
Tbbmd2MRL/MpJ
QTL Variant Detail
Summary
QTL variant: Tbbmd2MRL/MpJ
Name: total body bone mineral density 2; MRL/MpJ
MGI ID: MGI:2668924
QTL: Tbbmd2  Location: Chr2:117942930-117943090 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 59.34 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  MRL/MpJ
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81607

Genome scan using 119 polymorphic markers was performed on 633 (MRL/MpJ x SJL/J)F2 animals to identify QTLs associated with bone mineral density (BMD). Parental strain MRL/MpJ exhibits greater BMD compared to parental strain SJL/J. Two different methods,PIXIMUS and pQCT were used in the analysis.

Seven QTLs for total body bone mineral density (Tbbmd) were identified. Tbbmd1 mapped to mouse Chromosome 1 with peak linkage at D1Mit362 (110.4 cM, LOD=5.9). Tbbmd1 is also associated with femur BMD. Tbbmd2 and Tbbmd3 mapped to mouse Chromosome 2 with peak linkage at D2Mit62 (54.6 cM, LOD=5), and D2Mit263 (78.7 cM, LOD=7.2), respectively. Tbbmd4 mapped to mouse Chromosome 9 with peak linkage between D9Mit270 and D9Mit182 (43 cM - 55 cM, LOD=4.4). Tbbmd5 mappedto mouse Chromosome 11 with peak linkage at D11Mit36 (43.7 cM, LOD=6.8). Tbbmd6 mapped to mouse Chromosome 14 with peak linkage at D14Mit194 (52.5 cM, LOD=4.5). Tbbmd7 mapped to mouse Chromosome 17 with peak linkage at D17Mit175 (6.6 cM, LOD=5.8).

Suggestive loci with LOD scores < 3.5 mapped to chromosome 3 at D3Mit217 (43.7 cM), chromosome 12 at D12Mit201 (23 cM), chromosome 15 at D15Mit179 (7.7 cM), and chromosome 18 at D18Mit152 (25.1 cM). Loci at chromosomes 12 and 18 are associated with femur BMD.

References
Original:  J:81607 Masinde GL, et al., Quantitative trait Loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in f2 mice. Calcif Tissue Int. 2002 Nov;71(5):421-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory