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Fn1tm1Bwg
Targeted Allele Detail
Nomenclature
Symbol: Fn1tm1Bwg
Name: fibronectin 1; targeted mutation 1, Brigham and Women's Hospital
MGI ID: MGI:2668886
Synonyms: EIIIA-
Gene: Fn1  Location: Chr1:71585520-71653200 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90917
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTransient cre-mediated recombination left a single loxp site in place of the exon encoding the EIIIA domain. RT-PCR indicates absence of EIIIA expression. Immunohistochemistry of mutant cells shows no staining above background. (J:90917)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:  75 strains or lines available
References
Original:  J:90917 Tan MH, et al., Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood. 2004 Jul 1;104(1):11-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory