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Targeted Allele Detail
Symbol: Prkg1tm2Naw
Name: protein kinase, cGMP-dependent, type I; targeted mutation 2, Hermann Nawrath
MGI ID: MGI:2668652
Synonyms: CGKIL2
Gene: Prkg1  Location: Chr19:30567551-31765033 bp, - strand  Genetic Position: Chr19, 25.17 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:84611
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 10 was left flanked by loxP sites after the homologous recombination of a targeting vector containing a single loxP site upstream of exon 10 and tk-neo cassette with a 3' loxP site in intron 10. (J:84611)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkg1 Mutation:  28 strains or lines available
Original:  J:84611 Wegener JW, et al., cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res. 2002 Jan 11;90(1):18-20
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory