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Targeted Allele Detail
Symbol: Rad23atm1Jhjh
Name: RAD23 homolog A, nucleotide excision repair protein; targeted mutation 1, Jan H J Hoeijmaker
MGI ID: MGI:2668469
Synonyms: mHR23A-
Gene: Rad23a  Location: Chr8:84834652-84840736 bp, - strand  Genetic Position: Chr8, 41.2 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:84299
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 2, all of exons 3-6, and part of exon 7 were replaced with a neomycin resistance marker. This deletes about 85% of the coding sequence (amino acid residues 55-288). mRNA and protein cannot be detected in homozygous E13.5 embryonic fibroblasts. (J:84299)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad23a Mutation:  5 strains or lines available
Original:  J:84299 Ng JM, et al., A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev. 2003 Jul 1;17(13):1630-45
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
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