Rad23a^tm1Jhjh
Targeted Allele Detail

Summary

• Symbol: Rad23a^tm1Jhjh
• Name: RAD23 homolog A, nucleotide excision repair protein; targeted mutation 1, Jan H J Hoeijmaker
• MGI ID: MGI:2668469
• Synonyms: mHR23A^-
• Gene: Rad23a Location: Chr8:85561540-85567361 bp, - strand Genetic Position: Chr8, 41.2 cM, cytoband C3
• Alliance: Rad23a^tm1Jhjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84299
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2, all of exons 3-6, and part of exon 7 were replaced with a neomycin resistance marker. This deletes about 85% of the coding sequence (amino acid residues 55-288). mRNA and protein cannot be detected in homozygous E13.5 embryonic fibroblasts. (J:84299)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad23a Mutation: 12 strains or lines available

References

• Original: J:84299 Ng JM, et al., A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev. 2003 Jul 1;17(13):1630-45
• All: 2 reference(s)