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Targeted Allele Detail
Symbol: Mt2tm1Rch
Name: metallothionein 2; targeted mutation 1, Anna E Michalska
MGI ID: MGI:2668455
Synonyms: MT-II -, MT-null
Gene: Mt2  Location: Chr8:94172664-94173568 bp, + strand  Genetic Position: Chr8, 46.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:14416
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsBoth metallothionein I and II were disrupted using the same targeting construct. The second exon of metallothionein II had an insertion of the pMC1NeoPA selection marker at a position 30bp downstream of the start codon. Northern blot analysis of liver mRNA from homozygotes in which the gene was induced by intraperitoneal injection of copper demonstrated that transcription was prevented. Further, no protein product was detected in the livers of these animals. (J:14416)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mt2 Mutation:  5 strains or lines available
Original:  J:14416 Michalska AE, et al., Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8088-92
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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