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Ifnar1tm1Pjh
Targeted Allele Detail
Nomenclature
Symbol: Ifnar1tm1Pjh
Name: interferon (alpha and beta) receptor 1; targeted mutation 1, Paul J Hertzog
MGI ID: MGI:2667975
Synonyms: IFNAR1 -
Gene: Ifnar1  Location: Chr16:91485238-91507441 bp, + strand  Genetic Position: Chr16, 52.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36004
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a neo cassette into exon 5. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:36004)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ifnar1 Mutation:  18 strains or lines available
References
Original:  J:36004 Hwang SY, et al., A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11284-8
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory