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Targeted Allele Detail
Symbol: Dclre1ctm1Fwa
Name: DNA cross-link repair 1C; targeted mutation 1, Frederick W Alt
MGI ID: MGI:2667614
Synonyms: Artdelta, Artemis-, ArtN
Gene: Dclre1c  Location: Chr2:3424131-3464130 bp, + strand  Genetic Position: Chr2, 1.93 cM
Germline Transmission:  Earliest citation of germline transmission: J:80995
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 5 and 6 were replaced with a floxed neo cassette inserted by homologous recombination. While normal transcript was undetected by RT-PCR analysis of homozygous mutant kidney tissue, truncated transcript comprised of exons 1 through 4 was detected. The shortened transcript lacked sequence encoding 2 of the 4 zinc binding motifs. (J:80995)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dclre1c Mutation:  16 strains or lines available
Original:  J:80995 Rooney S, et al., Leaky scid phenotype associated with defective v(d)j coding end processing in artemis-deficient mice. Mol Cell. 2002 Dec;10(6):1379-90
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory