About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Trpv4tm1Msz
Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1, Makoto Suzuki
MGI ID: MGI:2667379
Synonyms: Trpv4-, TRPV4KO
Gene: Trpv4  Location: Chr5:114622152-114658421 bp, - strand  Genetic Position: Chr5, 55.99 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:84093
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance gene was inserted into exon 4 which encodes the ankyrin-repeat domain. Transcripts were undetectable by RT-PCR and Northern blot in trigeminal root and dorsal root ganglia of homozygous animals. Immunohistochemical staining of the dorsal root ganglion confirmed the success of gene disruption. (J:84093)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpv4 Mutation:  5 strains or lines available
Original:  J:84093 Suzuki M, et al., Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003 Jun 20;278(25):22664-8
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory