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Allele Detail
Symbol: Ahrb-1
Name: aryl-hydrocarbon receptor; b-1 variant
MGI ID: MGI:2667308
Synonyms: Ah, Ahb, Ahb-1, Ahhi, Ahrb, In
Gene: Ahr  Location: Chr12:35547978-35584988 bp, - strand  Genetic Position: Chr12, 15.78 cM
Ahrb-1/Ahrb-1 Aiptm2.1Bra/Aiptm2.1Bra Speer6-ps1Tg(Alb-cre)21Mgn/0 mice are resistant to dioxin-induced hepatic damage

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Not Applicable
Mutation:    Nucleotide substitutions
Mutation detailsThis allele encodes a high affinity, relatively heat stabile, 95 kDa receptor. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). A second C to T transition changes a proline codon in the DBA/2J allele to leucine codon in the C57BL/6J allele, and would likely change secondary structure of the peptide and thus ligand affinity. (J:477, J:15153, J:17460)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 13 strains available      Cell Lines: 0 lines available
Carrying any Ahr Mutation:  94 strains or lines available
C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460).

Strain of origin - this allele was found in C57BL/6, C58/J, C57BR, MA/My strains

Original:  J:26440 Schmid FA, et al., Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res. 1967 Mar;27(3):558-62
All:  52 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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