About   Help   FAQ
Nsd1tm1.1Pcn
Targeted Allele Detail
Nomenclature
Symbol: Nsd1tm1.1Pcn
Name: nuclear receptor-binding SET-domain protein 1; targeted mutation 1.1, Pierre Chambon
MGI ID: MGI:2667262
Synonyms: NSD1-
Gene: Nsd1  Location: Chr13:55209782-55318325 bp, + strand  Genetic Position: Chr13, 29.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83923
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated by crossing mice heterozygous for Nsd1tm1Pcn with cytomegalovirus-Cre mice which express the Cre recombinase in the germline. Animals in which Cre-mediated excision of the neomycin gene and exon 2 occurred were detected by PCR analysis. (J:83923)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nsd1 Mutation:  193 strains or lines available
References
Original:  J:83923 Rayasam GV, et al., NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J. 2003 Jun 16;22(12):3153-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory