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Tab1tm1Geny
Targeted Allele Detail
Nomenclature
Symbol: Tab1tm1Geny
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1; targeted mutation 1, Gen Yamada
MGI ID: MGI:2667182
Gene: Tab1  Location: Chr15:80133127-80161707 bp, + strand  Genetic Position: Chr15, 37.85 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80766
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced two exons encoding amino acids 308 through 336. Normal protein was undetected by Western blot analysis of homozygous mutant MEFs. (J:80766)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tab1 Mutation:  59 strains or lines available
References
Original:  J:80766 Komatsu Y, et al., Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002 Dec;119 Suppl 1(2):239-49
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory