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Drap1tm1Mms
Targeted Allele Detail
Nomenclature
Symbol: Drap1tm1Mms
Name: Dr1 associated protein 1 (negative cofactor 2 alpha); targeted mutation 1, Michael M Shen
MGI ID: MGI:2667159
Synonyms: Drap1-
Gene: Drap1  Location: Chr19:5422805-5424979 bp, - strand  Genetic Position: Chr19, 4.32 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80667
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing all of exon 2 and a portion of exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded amino acids 13 through 65, which make up a portion of the alpha helix of the mature protein. (J:80667)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drap1 Mutation:  3 strains or lines available
References
Original:  J:80667 Iratni R, et al., Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science. 2002 Dec 6;298(5600):1996-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory