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Blnktm1Dkit
Targeted Allele Detail
Summary
Symbol: Blnktm1Dkit
Name: B cell linker; targeted mutation 1, Daisuke Kitamura
MGI ID: MGI:2665856
Synonyms: BASH-
Gene: Blnk  Location: Chr19:40917371-40982664 bp, - strand  Genetic Position: Chr19, 34.26 cM
Alliance: Blnktm1Dkit page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84040
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by a polyadenylation signal inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant splenic cells. Germline transmission of the allele generated in J:80920 was achieved in J:85014. (J:80920, J:84040)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blnk Mutation:  68 strains or lines available
References
Original:  J:84040 Hayashi K, et al., Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity. 2003 Jun;18(6):825-36
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory