Pth^tm1Dgo
Targeted Allele Detail

Summary

• Symbol: Pth^tm1Dgo
• Name: parathyroid hormone; targeted mutation 1, David Goltzman
• MGI ID: MGI:2665181
• Synonyms: PTH^-
• Gene: Pth Location: Chr7:112984787-112987777 bp, - strand Genetic Position: Chr7, 59.19 cM, cytoband F
• Alliance: Pth^tm1Dgo page

Skeletal phenotypes and tibial histology of Pth^tm1Dgo/Pth^tm1Dgo, Pthlh^tm1Hmk/Pthlh^tm1Hmk and Pth^tm1Dgo/Pth^tm1Dgo Pthlh^tm1Hmk/Pthlh^tm1Hmk mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76407
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunohistochemistry of parathyroid glands. (J:76407)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pth Mutation: 15 strains or lines available

References

• Original: J:76407 Miao D, et al., Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest. 2002 May;109(9):1173-82
• All: 26 reference(s)