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Mark2Gt(pSABetageo)38Bss
Gene trapped Allele Detail
Nomenclature
Symbol: Mark2Gt(pSABetageo)38Bss
Name: MAP/microtubule affinity regulating kinase 2; gene trap 38, Stephanie Bessone
MGI ID: MGI:2665175
Gene: Mark2  Location: Chr19:7275396-7341860 bp, - strand  Genetic Position: Chr19, 5.32 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57958
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector
 
Mutation detailsThe endogenous locus was disrupted by the random integration of a gene trap vector containing a splice acceptor site followed by beta-geo. Sequence and RT-PCR analysis showed that the insertion was intronic and was in between the start codon and sequence encoding the kinase domain. (J:57958)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mark2 Mutation:  57 strains or lines available
References
Original:  J:57958 Bessone S, et al., EMK protein kinase-null mice: dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways. Dev Biol. 1999 Oct 1;214(1):87-101
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory