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Tg(TcrLCMV)327Sdz
Transgene Detail
Nomenclature
Symbol: Tg(TcrLCMV)327Sdz
Name: transgene insertion 327, Birgit Ledermann
MGI ID: MGI:2665105
Synonyms: P14, P14 TCR, P14-TCR, P14 TCR-alphabeta (Valpha2Vbeta8.1), P14 TCRValpha2Vbeta8, TCR LCMV, TCR P14, TCR-Tg, TgTcr
Transgene: Tg(TcrLCMV)327Sdz  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcrLCMV)327Sdz expresses 2 genes
 
Mutation detailsThe transgene carries both Tcra and Tcrb. Ten to twenty copies of the Tcr transgene were reported to have integrated on the same chromosome. At least two transgenic lines are known to exist. Line 327 is the representative line. The second line is 318. (J:77696)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Notes
Transgenic mice carry a T-cell receptor (Tcra-V2, Tcra-J TA31 / Tcrb-V8.1, Tcrb-D, Tcrb-J 2.4) specific for LCMV (lymphocytic choriomeningitis virus), H2-Db.
References
Original:  J:77696 Pircher H, et al., Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature. 1989 Nov 30;342(6249):559-61
All:  244 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory