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Tg(Igh-Abl1)40Sco
Transgene Detail
Nomenclature
Symbol: Tg(Igh-Abl1)40Sco
Name: transgene insertion 40, Suzanne Cory
MGI ID: MGI:2665029
Synonyms: EmuSV-v-abl, Emu-v-abl
Transgene: Tg(Igh-Abl1)40Sco  Location: unknown  Genetic Position: Chr14, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6JWehi X SJL/JWehi)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene used the mouse Igh enhancer and the SV40 early promoter region to drive a gag-Abl1 fusion sequence in lymphoid cells. The transgene is expressed in hematopoietic tissues and in all tumors. (J:78204)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Four transgenic lines were created. Line v-abl 1 harbors more than 1 transgene and exhibits only lymphomas (will be described elswhere). Lines v-abl 40, v-abl 8, and v-abl 2 develop plasmocytomas.

References
Original:  J:78204 Rosenbaum H, et al., An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene. EMBO J. 1990 Mar;9(3):897-905
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory