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Men1tm1.1Zqw
Targeted Allele Detail
Nomenclature
Symbol: Men1tm1.1Zqw
Name: multiple endocrine neoplasia 1; targeted mutation 1.1, Zhao-Qi Wang
MGI ID: MGI:2664873
Synonyms: Men1D, Men1delta, Men1Δ
Gene: Men1  Location: Chr19:6334979-6340891 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83882
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was derived from Men1tm1Zqw by transfecting targeted ES cells with a Cre-expressing plasmid (pMC-Cre). The neo gene, TK gene, and exon 3 were then removed by Cre-mediated recombination. Western blot analysis demonstrated that no detectable protein product is expressed from this allele in mutant ES cells. (J:83882)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  25 strains or lines available
References
Original:  J:83882 Bertolino P, et al., Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech Dev. 2003 May;120(5):549-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory