Akt2^tm1Rsg
Targeted Allele Detail

Summary

• Symbol: Akt2^tm1Rsg
• Name: thymoma viral proto-oncogene 2; targeted mutation 1, Robert S Garofalo
• MGI ID: MGI:2664498
• Synonyms: Akt2^-, Akt2 KO, PKBbeta^-
• Gene: Akt2 Location: Chr7:27290977-27340251 bp, + strand Genetic Position: Chr7, 15.94 cM, cytoband B1
• Alliance: Akt2^tm1Rsg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83741
• Parent Cell Line: DBA-252 (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced 3.4kb of sequence which includes three exons containing part of the catalytic domain. Western blot analysis confirmed the absence of protein product. (J:83741, J:84606)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Akt2^tm1Rsg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt2 Mutation: 51 strains or lines available

References

• Original: J:83741 Peng XD, et al., Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 2003 Jun 1;17(11):1352-65
• All: 12 reference(s)