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Akt2tm1Rsg
Targeted Allele Detail
Nomenclature
Symbol: Akt2tm1Rsg
Name: thymoma viral proto-oncogene 2; targeted mutation 1, Robert S Garofalo
MGI ID: MGI:2664498
Synonyms: Akt2-, Akt2 KO, PKBbeta-
Gene: Akt2  Location: Chr7:27591557-27639453 bp, + strand  Genetic Position: Chr7, 15.94 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83741
Parent Cell Line:  DBA-252 (ES Cell)
Strain of Origin:  DBA/1LacJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced 3.4kb of sequence which includes three exons containing part of the catalytic domain. Western blot analysis confirmed the absence of protein product. (J:83741, J:84606)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt2 Mutation:  25 strains or lines available
References
Original:  J:83741 Peng XD, et al., Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 2003 Jun 1;17(11):1352-65
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory