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Targeted Allele Detail
Symbol: Hsf2tm1Miv
Name: heat shock factor 2; targeted mutation 1, Nahid F Mivechi
MGI ID: MGI:2664486
Synonyms: Hsf2-
Gene: Hsf2  Location: Chr10:57486385-57513135 bp, + strand  Genetic Position: Chr10, 29.19 cM, cytoband B3-B4
Testes are smaller in Hsf2tm1Miv/Hsf2tm1Miv and Hsf1tm1Miv/Hsf1tm1Miv Hsf2tm1Miv/Hsf2tm1Miv mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:83730
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding sequence of exon 1 was replaced with an EGFP-neo cassette which caused the termination of transcription. The neomycin resistance gene was flanked by loxP sites. Correct targeting was demonstrated by Southern blot. Transcripts were lacking in northern blots of total liver RNA from mice homozygous for the targeted allele and no Hsf2 protein expression was seen in western blots. (J:83730)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 48 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsf2 Mutation:  22 strains or lines available
Original:  J:83730 Wang G, et al., Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003 May;36(1):48-61
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory